Questions On Breast Cancer Progression Essay - 1213 Words

Discussion: Breast cancers mostly invade into adjacent regions and metastasize to lymph nodes and distant organs. To develop novel treatments strategies, it is essential to address factors underlying tumorgenesis, invasion and metastasis. In this study, we identified Bmi-1, S100A4 and claudin-1 as important players in breast cancer progression. The current study illustrated the expression of these markers in primary breast cancer tissues, followed by demonstrating the association between their expressions and clinicopathological features and finally addressed their role in breast cancer prognosis. Regarding Bmi-1, in our study it was expressed in 58% of breast cancer cases; nearby results were reported by other investigators in their immunohistochemical studies (Kim et al., 2004; Choi et al., 2009; Guo et al., 2011; Wang et al., 2012). Moreover, there was a significant association between Bmi-1 expression and histopathological type, tumor grade, lymphovascular invasion, nodal metastasis, distant metastasis and tumor stage. These results confirm the intimate relation between Bmi-1 and breast cancer progression leading to aggressive behavior. These correlations are similar to results observed by Guo et al., 2011; Zhang et al., 2010; Wang et al., 2012). Guo et al.,2011 observed that over 90% of the late-stage cases (stages III/IV) showed high Bmi-1 expression, whereas less than 50% of the early-stage cases (stages I/II) showed high expression. Moreover, they found that 67.1% ofShow MoreRelatedThe Treatment Of Breast Cancer1134 Words   |  5 PagesBreast cancer affects so many w omen around the world. Even with the technology and medicine we have today to treat this deadly disease, the pain a patient experiences with breast cancer is still relentless. Pain comes from either progression of the disease or a side effect from treatment. In this article they talk about the role of the WHO’s three step analgesic ladder and how the administration of opioids for breast cancer patients experiencing pain effect ones psychological state and their qualityRead MoreBreast Cancer Patients Treated With Endocrine Therapy1592 Words   |  7 PagesWhen it is assumed that 40 % of breast cancer patients treated with endocrine therapy are resistant to this therapy it becomes a problem within the health world, because that such a larger number of patients are not being cured from this treatment. Researchers have studied the Cyclin D1 (CCND1) amplification for being the possible cause for tamoxifen resistance. Cyclin D1 is found within 10-20% of breast cancer patients maki ng it a prime suspect too why patients are becoming resistant to treatmentRead MoreCp55 Case Study1225 Words   |  5 Pagesa marker of malignancy risk, prognosis and therapy outcome CEP55 has been identified in the prognostic signature for multiple cancers as demonstrated in Table 1 (have to insert the table). Carter et al. have shown that CEP55 is part of the top 70 genes identified as responsible for CIN (CIN70 signature) from analysis involving 12 cancer types such as lung, breast, glioma, memedulloblastoma, mesothelioma and lymphoma [276]. CIN70 along with its subset CIN25 significantly correlate with clinicalRead MoreQualitative Research Critique II 2843 Words   |  4 PagesMBSR training for women with breast cancer. They did six meta-analyses that examined people’s psychological distress (Rouleau, Garland, Carlson, 2015, pg. 121). During this study, there were questions asked to the participants. The authors ensured that the questions were open ended and in a non-directive manner. It allowed the participants to be able to speak freely about their experiences (Schellenkens Jansen, 2015, pg. 1814). This article gave one question that the authors, SchellenkensRead MoreThe Effects Of Genetic Mutations On Dna Repair Systems And Mutations883 Words   |  4 PagesSeveral decades of cancer research have identified thousands of mutation causing carcinogens, genetic mutations in DNA repair systems and mutations that cause dysregulation in critical signal pathways involved in cell cycle progression, cell growth and programmed cell death. Human cancers cannot be classified as a single disease because they are each unique on the molecular level. Often the same documented cancer type can inflict two patients with similar symptoms, but the required treatment forRead MoreResearch On Cancer And Psychology1610 Words    |  7 PagesQinyue Ban Prof. Scala WRI 102 14 Nov. 2014 Cancer and Psychology The common argue which in medical area is the scientist’s keen to research about the relationship between the cancer and psychology. Cancer is comment disease, also as known as malignant tumors, has become a threat to human health and life of common disease, even become a major case of human death. Cancer occurred for any age, race, and gender. The reason and the result of the cancer are different because of the diverse of populationRead MoreSymptoms And Treatment Of Cancer Essay1214 Words   |  5 PagesCancer remains a major disease in the United States and causes a burden not just to individuals but also to the society in general. It was estimated more than 1.6 million new cases will be diagnosed in the United States in 2016, and approximately 600,000 patients will succumb to cancer1. Through the effort of screening (mammography for breast cancer, colonoscopy for colon cancer, to name a few) some cancers can now be detected early on when local resection is still feasibl e. However, many cancersRead MoreThe Importance Of Detection Of Breast Cancer Cells1211 Words   |  5 PagesBreast cancer is the most common cause of cancer-related death in women and it is estimated that in 2017, 5000 women will die of this disease in Canada2. The main reason for death is due to metastases in other organs and circulating tumour cells (CTCs) may be the main cause of metastatic lesions1. CTCs detach from the primary tumour and travel through blood or lymphatic vessels to form a secondary tumour1. The purpose of the 2016 preliminary study was to determine if CTCs can be detected in the bloodRead MoreHow Metastasis Is An Complex Process1570 Words   |  7 PagesMetastasis is an extraordinarily complex process. A sequence of steps is executed by a cancer cell to successfully form distant colonies at a secondary site. Typically, cancer cells escape from the primary tumour, break through basement membrane and invade surrounding tissues, encounter the circulatory syste m and/or lymphatics and travel to distant sites. Finally, they are arrested in small capillaries while being able to grow and form new tumours.[1] Tumour cells acting through this multistep metastaticRead MoreWhat Is The Cost Effectiveness Of Infliximab1619 Words   |  7 PagesSeven articles were finally evaluated in accordance with PRISMA guidelines. All of these papers found explaining the research question and the economic evaluation explicitly. Ron Goeree et al., studied cost-effectiveness of secukinumab 150 mg and 300 mg compared to subcutaneous biologics adalimumab, certolizumab pegol, etanercept, golimumab, and ustekinumab, and intravenous biologics infliximab and infliximab biosimilar in biologic-naive and biologic-experienced patients over a lifetime horizon

Labeling Youths...and The Consequences Thereof - 1394 Words

A child’s self-esteem often times comes from their status in a group of their peers, their family, school life and in society. With that in mind, society still decides to label youths as deviants, delinquents and status offenders ultimately changing their own views on their self-image. This affects the way youths think about themselves and how they will play a role in society. It also affects the way society will later treat them and whether or not they become an outsider. Labeling youths is an unnecessary evil that often times changes children into criminals. To understand labeling we must first look at its definition. Labeling Theory is a theoretical approach to deviant behavior, basically stating that applying formal definitions to an†¦show more content†¦If the judge concludes that the juvenile committed the offense, the judge does not find the juvenile â€Å"guilty† but â€Å"delinquent†. (Fagin 241) The judge also has the ability of sentencing the delinquent to community service, a juvenile detention center or another fit form of punishment. Authorities and teachers then treat â€Å"delinquent† children differently and several studies suggested that under certain circumstances, â€Å"official punishment appears to increase the likelihood of subsequent deviance as suggested by labeling theory.† (Bartollas 130) Labeling is not just found in society and the justice system or at home. It usually begins at school where a child’s achievements, behavior and temperament are placed on a scale to determine normalcy. Should a child be difficult to manage, a slow learner or aggressive they may be diagnosed with ADD, ADHD or placed in Special Needs/Education classes. This separates them from their friends and other children inadvertently labeling them as different. The treatment of these children is different than those in regular classes and programs. Sometimes children may not be able to perform satisfactorily in school which leads them to become â€Å"disruptive, decide to drop out or are suspended – all of which further reinforces involvement in deviant behavior. (Bartollas 207) Without a proper education children grow and fend for themselves. They are left with minimum wage jobs orShow MoreRelatedThe Censorship of Art Essay example14698 Words   |  59 Pagesfinally shifted to Cap itol Hill, where a hearing was held before the Senate Committee on Commerce, Science, and Transportation on what by then had come to be known as the issue of porn rock. 2. The Senate Hearing on Record Labeling The Senate Hearing on record labeling, held on September 19, 1985, was arguably the best attended and media-covered hearing ever held before any Senate Committee (Gray 1989a:153-155, 1989b:8-10; Kaufman 1986:231-233; Roldan 1987:231-240; Scheidemantel 1985-1986:467-470;Read MoreThe Role Of Male Teachers And Academic And. 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My Dog Seeka Essay Example For Students

My Dog Seeka Essay Our first family pet was a black lab/German Shepherd mix named Cheyenne. My parents adopted her as a puppy before I was even born, and she was considered a part of the family. She had black fur all over except for her tan underside, and her face resembled a raccoon. As far back as I can remember she was always very docile, and well behaved to the point we could let her go outside and call her back a few minutes later without having to worry about her running away. She was a part of our family for 10 years. Unfortunately, when we moved to Canada, we had to put her up for adoption as we couldnt bring her with us. Around the age of 6 we adopted another dog named Emily. She was a pure breed black lab, with pitch black fur all over. She was fairly violent, and we had a lot of trouble with her training, to the point where we had to keep her in a crate most of the time. We only had Emily for 2 years before we put her up for adoption. Around the same age we also had a few cats. Peaches, an over weight, orange cat originally belonged to us, but he got out one day and we were never able to keep him in the house again. Yet strangely enough, he never left the area, and even followed us when we moved a few miles down the street. Our other cat was named Sevens. She was mostly gray with a few darker gray stripes down her back. We never had Sevens spayed, and as a result she ended up have 3 litters of kittens throughout her life, but we never kept any of the kittens. It was never confirmed, but we always believed Peaches was the father. A slightly less memorable pet, but I will never forget was an oscar fish simply named Oscar. I mostly remember Oscar because we had a lot of fun feeding his minnows. We owned all of these pets throughout the first 9 or 10 years of my life, and around that time we moved to Canada. My parents wanted to make sure that we always had a family pet so they immediately went on a search. The first pet we owned in Canada was a golden retriever/beagle mix puppy named Tess. She was definitely more beagle, but she has pure golden fur. We also adopted a black lab named Sam shortly after. I really dont remember much about them aside from how much trouble we had with their house training. There was a very large field full of tall grass and weeds at the end of our street, and we would take them out there and let them run around and play for a while, which turned out to be a bad idea when one day they run pretty far out, too far for us to see, and eventually they were gone. They turned up in a kennel a few days later but we didnt have the money to get them back, so that was the last we saw of them. We waited a few months before we tried to adopt any new pets, but my father always knew exactly what he wanted. His favorite breed of dog were huskies, and we found a husky trainer a few hours north, and that is where we adopted Komo and Seeka, two pure breed huskies. Komo was the more traditional looking husky; a mix of thick black and white fur with icy blue eyes. He quickly grew attached to my father and he couldnt have been happier with the outcome. Komo was around eight years old, so he was usually very docile and enjoyed curling up on the couch with my father. Seeka was younger, somewhere around three, slender when compared to Komo, and had snow white fur with patches of brown. .u6579733ae246990199b935267b559e33 , .u6579733ae246990199b935267b559e33 .postImageUrl , .u6579733ae246990199b935267b559e33 .centered-text-area { min-height: 80px; position: relative; } .u6579733ae246990199b935267b559e33 , .u6579733ae246990199b935267b559e33:hover , .u6579733ae246990199b935267b559e33:visited , .u6579733ae246990199b935267b559e33:active { border:0!important; } .u6579733ae246990199b935267b559e33 .clearfix:after { content: ""; display: table; clear: both; } .u6579733ae246990199b935267b559e33 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u6579733ae246990199b935267b559e33:active , .u6579733ae246990199b935267b559e33:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u6579733ae246990199b935267b559e33 .centered-text-area { width: 100%; position: relative ; } .u6579733ae246990199b935267b559e33 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u6579733ae246990199b935267b559e33 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u6579733ae246990199b935267b559e33 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u6579733ae246990199b935267b559e33:hover .ctaButton { background-color: #34495E!important; } .u6579733ae246990199b935267b559e33 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u6579733ae246990199b935267b559e33 .u6579733ae246990199b935267b559e33-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u6579733ae246990199b935267b559e33:after { content: ""; display: block; clear: both; } READ: 4)The Application of Science to Engineering EssayShe had one brown eye and one blue eye, which I thought made her more unique. She was a beautiful dog, but when we first adopted her along with Komo, she was very shy. She would stay away from everyone, wouldnt really do much. One day, I stayed home sick, I was the only one home so my parents let me spend the day in their bed, and I kept Seeka in the room with me. After taking a nap, I woke up to see Seeka laying on the bed with me. She was so warm and soft, so I curled up with her, and from that day she was MY dog. She was still shy with the rest of the family, but she was always so excited whenever I was around. She would always follow me around, jump up to try and lick my face, it even got to the point where I could walk around the corner while someone was holding her, and she would start to whine until I came back around. I had my dad take apart my loft bed so she could sleep with me at night shortly after she grew attached to me. I remember during the winter, we would hook her leash up to a sled and she would pull me around the block until she tired herself out. This was the first time I ever had that â€Å"boy and his dog† kind of relationship with a pet. I loved Seeka, and she loved me. I never waned to lose her, but things took a bad turn far too soon. About a year and a half after we moved to Canada, and about a year after we adopted Komo and Seeka, my father was laid off. He tried to find another job, unfortunately, with no avail. We tried our best but we were evicted from our house, and at the time we had to move in with some relatives in New York until we could find a new house to move to. What made this worse was that there wasnt enough room in the house for Komo and Seeka, so we were afraid we would have to give them up. It was devastating, but we had one glimmer of hope that made everything better. The kennel we adopted them from promised that they would hold onto them and take care of them until we could take them back. It was sad saying goodbye to Seeka, but it was OK because it would only be a few months. Time had gone by, we moved into a new house, and it was time to go and get the dogs back. When we called the kennel, they very coldly told us they had sold Komo and Seeka, and told us they never made that promise. There was nothing we could do, because we never got it in writing so we had no way to prove it or even take any sort of legal action. I was crushed. At this point in my life, I had never lost a loved one, and never got this close to any of our other pets, so this was the worst moment in my life. Knowing that not only would I never see Seeka again, but that she was still out there somewhere made it even worse. I didnt know what to do, and no one had any answers. In the end, I could do nothing. I had to live with this now, and even to this day I still miss Seeka.